Carl Gustaf Saluste, Ph.D.

Department of Natural Sciences
Chemistry

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Education

M.Sc., University of Lund, Sweden (1996)
Ph.D., University of Southampton, UK (2001)

Practice Areas

• Organic Chemistry (synthesis and methodology)

Publications and Media Placements

Saluste, C.G., Ortega M.A., Pastor, J. et al. “Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors. Plos One, 2012, 7, 1.

Martínez, S., Hernández, A.I., Rodríguez, A., Saluste, C.G. et al. “Identification of ETP-46321, a potent and orally bioavailable PI3Ka,d ,-inhibitor”. Bioorg. Med. Chem. Lett. 2012, 22, 3460.

Pastor, J., Oyarzabal, J., Saluste, C.G. et al. “Hit-to lead evaluation of 1,2,3-Triazolo [4,5-b] pyridines as PIM-kinase inhibitors”. Bioorg. Med. Chem. Lett., 2012, 22, 1591.

Martin, M.W., Newcomb, J., Ghiron, C., Saluste, C.G. et al. “Structure-based design of novel 2-amino-6-phenyl-pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR and in vivo anti-inflammatory activity”. J. Med. Chem., 2008, 51, 1637.

Saluste, C.G., Crumpler, S., Furber, M., Whitby, R.J. “Palladium-catalysed synthesis of cyclic amidines and imidates”. Tetrahedron Letters, 2004, 45, 6995.

Whitby, R.J., Saluste, C.G., Furber, M. “Synthesis of a-iminoimidates by palladium-catalysed double isonitrile insertion”. Org. Biomol. Chem., 2004, 2, 1974.

C.G. Saluste, C. Ghiron-Thomas, M. Ermann, P. Amouzeg and E. Power, Patent application with AMGEN Pharmaceuticals, July 2003.

C.G Saluste, R.J Whitby and M. Furber, “Palladium-catalysed synthesis of imidates, thioimidates and amidines from aryl halides”, Tetrahedron Lett., 2001, 42, 6191.

C.G Saluste, R.J Whitby and M. Furber, “A Palladium catalysed synthesis of amidines from aryl halides”, Angew. Chem. Int. Ed. Engl., 2000, 89, 4156.

C.G. Saluste, U. Berg, N. Bladh, A. Hjelmencrantz and M. Stodeman “Structure and Dynamic Stability of Cyclodextrin Inclusion Complexes with 1,4-Disubstituted Bicyclo-[2.2.2]octanes”. Poster Presentation, 8th Meeting on Stereochemistry August 1998, Tepla, Czeck Republic.

Patents:

Nunes, J., Xiotian, Z., Saluste, C.G. et al. “Substituted Heterocycles and Methods of Use”. WO/2005/021551.

Pastor, J., García-Collazo, A.M., Saluste, C.G. et al. “Tricyclic Compounds for Use as Kinase Inhibitors”. WO/2011/080510.

Pevarello, P., García-Collazo, A.M., Saluste, C.G. et al. “Imidazopyridazines for Use as Protein Kinase Inhibitors”. US/2011/0046127.

Pastor, J., Oyarzabal, J., Saluste, C.G. et al. “Triazolo [4,5-b]pyridine derivatives”. WO/2011/101644.

Stay as guest researcher:

05/2017-07/2017: CNIO, Madrid, Spain: Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Crosslinkers to be tested for incorporation to Kinase inhibitors.

01/2015-05/2015: Universidad Complutense, Madrid, Spain: Preparation of synthetic metabolites for pathogenic bacteria, part of the human bacteriotal.